Gut bacteria may increase bowel cancer risk
Researchers have found that people with a certain type of bacteria in
their gut may be at a greater risk of developing bowel cancer. The gut
microbiome is the collection of fungi, bacteria and viruses within our
gut. There is an increasing evidence that the make-up of the microbiome
plays a role in human health and the body's susceptibility to disease.
"In the first study to use a technique called Mendelian randomisation to investigate the causal role played by bacteria in the development of bowel cancer, we found evidence that the presence of an unclassified type of bacteria from a bacterial group called Bacteroidales increased the risk of bowel cancer by between 2-15 per cent," said study researcher Kaitlin Wade from the University of Bristol in UK.
This means that, on an average, people with this type of bacteria within their guts may have a slightly higher risk of bowel cancer as compared to those who don't. For the study, the researchers used data from 3,890 people taking part in the Flemish Gut Flora Project, the German Food Chain Plus study and the PopGen study, and 120,328 people in the international Genetics and Epidemiology of Colorectal Cancer Consortium.
These genome-wide association studies (GWAS) searched for small variations in the genomes of participants that occur more frequently in people with a particular disease or characteristic than in people without that disease or characteristic.
They also found that genetic variation in the population in particular parts of the genome were linked to the presence or varying amounts of 13 types of gut bacteria, and that people with an unclassified type of bacteria from the Bacteroidales group had a higher risk of bowel cancer compared to people who did not have these bacteria.
"In the first study to use a technique called Mendelian randomisation to investigate the causal role played by bacteria in the development of bowel cancer, we found evidence that the presence of an unclassified type of bacteria from a bacterial group called Bacteroidales increased the risk of bowel cancer by between 2-15 per cent," said study researcher Kaitlin Wade from the University of Bristol in UK.
This means that, on an average, people with this type of bacteria within their guts may have a slightly higher risk of bowel cancer as compared to those who don't. For the study, the researchers used data from 3,890 people taking part in the Flemish Gut Flora Project, the German Food Chain Plus study and the PopGen study, and 120,328 people in the international Genetics and Epidemiology of Colorectal Cancer Consortium.
These genome-wide association studies (GWAS) searched for small variations in the genomes of participants that occur more frequently in people with a particular disease or characteristic than in people without that disease or characteristic.
They also found that genetic variation in the population in particular parts of the genome were linked to the presence or varying amounts of 13 types of gut bacteria, and that people with an unclassified type of bacteria from the Bacteroidales group had a higher risk of bowel cancer compared to people who did not have these bacteria.