Virus-inspired method to deliver drugs to brain
In a first, researchers have engineered small particles, similar to the size of viruses, to cross the protective border separating the circulating blood from the brain, an advance that may pave the way for improved drug delivery to the organ.
The study, noted that the new method allowed for combination drug delivery, through intravenous injections to cross the blood-brain-barrier(BBB).
The researchers, synthesised and modified components from a virus that targets the brain- a bacteriophage fd-- to deliver drugs across the BBB.
When the " small, hairy particle" that they developed was injected into mice, the system crossed the BB and targeted the brain, reaching neurons and other special brain cells, the study noted.
According to the researchers, most drugs are excluded from the brain by the protective blood-brain-barrier and current treatment options aimed at crossing this barrier were risky.
Crossing the BB has hindered the industry from effectively addressing central nervous system diseases, including brain tumours and many neurological diseases like Parkinson's, Alzheimer's and Huntington's, said the lead author of the study.
However, he added that some viruses have found ways to bypass the BB and enter the brain.
" We are very excited by our research-- our delivery system is versatile and amenable to modifications, so, in principle, we can hopefully address shortfalls in drug delivery to the brain through intravenous injection, said the author.
The new delivery system, based on more than a decade of research, has significant implications for developing drugs that can cross the BB, and other biological barriers, the researchers said.
The researchers said that the method may open up several opportunities to address neuro-degenerative diseases with modern therapeutics.
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Read more at: https://www.deccanherald.com/science-and-environment/virus-inspired-method-to-deliver-drugs-to-brain-study-767866.html
The study, noted that the new method allowed for combination drug delivery, through intravenous injections to cross the blood-brain-barrier(BBB).
The researchers, synthesised and modified components from a virus that targets the brain- a bacteriophage fd-- to deliver drugs across the BBB.
When the " small, hairy particle" that they developed was injected into mice, the system crossed the BB and targeted the brain, reaching neurons and other special brain cells, the study noted.
According to the researchers, most drugs are excluded from the brain by the protective blood-brain-barrier and current treatment options aimed at crossing this barrier were risky.
Crossing the BB has hindered the industry from effectively addressing central nervous system diseases, including brain tumours and many neurological diseases like Parkinson's, Alzheimer's and Huntington's, said the lead author of the study.
However, he added that some viruses have found ways to bypass the BB and enter the brain.
" We are very excited by our research-- our delivery system is versatile and amenable to modifications, so, in principle, we can hopefully address shortfalls in drug delivery to the brain through intravenous injection, said the author.
The new delivery system, based on more than a decade of research, has significant implications for developing drugs that can cross the BB, and other biological barriers, the researchers said.
The researchers said that the method may open up several opportunities to address neuro-degenerative diseases with modern therapeutics.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
https://gscrochetdesigns.blogspot.com. one can see my crochet creations
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
Read more at: https://www.deccanherald.com/science-and-environment/virus-inspired-method-to-deliver-drugs-to-brain-study-767866.html
Labels: Alzheimer's, blood-brain barrier, Brain, brain cells, Brain tumor, delivers, drugs to, Huntington's, intravenous injections, method, neurological diseases, neurons, Parkinson's, protective, virus-inspired
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