Lack of sleep affects fat metabolism

Healthy sleep habits can make a big difference in one's life but work week keeps us all a bit short on sleep, which can be severely harmful, says a study.

Researchers have reported that just a few days of sleep deprivation can make participants feel less full after eating and metabolise the fat in food differently.

Sleep disruption has been known to be having harmful effects on metabolism for some time.

One of the senior authors of the new study, contributed to a lot of research demonstrating that long-term sleep restriction puts people at a higher risk of obesity and diabetes.

However, he said, most of those studies have focused on glucose metabolism, which is important for diabetes, while relatively few have assessed digestion of lipids from food.

Another researcher said that after participants spent a week getting plenty of sleep at home, the 15 healthy men in their 20s checked into the sleep lab for the ten-night study.

For 5 of those nights, the participants spent no more than 5 hours in bed each night.

To find out how the uncomfortable schedule affected metabolism, the researchers gave participants a standardised high-fat dinner, a bowl of chili mac, after 4 nights of sleep restriction.

It was very palatable- none of our subjects had trouble finishing it- but very calorically dense, she said. Most participants felt less satisfied after eating the same rich meal while sleep-deprived than when they had eaten it well-rested.

Then researchers compared blood samples from the study participants. They found that sleep restriction affected the postprandial lipid response, leading to faster clearance of lipids from the blood after a meal.

This study was highly controlled, which makes it an imperfect model for the real world, she said. It focused on healthy young people, who are usually at a lower risk of cardiovascular disease, and all of the participants were men.

The researchers also wondered whether giving more recovery time would change the magnitude of recovery they observed.

Nonetheless, according to the lead author, the study gives worthwhile insight into how we handle fat digestion.


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