Drug for Alzheimer's disease increases hospitalisation risk

 Researchers have found that a drug, donepezil commonly used to manage symptoms of Alzheimer disease and other forms of dementia, is associated with a two-fold higher risk of hospitalisation.

According to the study, using donepezil increases the risk of hospital admission for rhabdomyolysis, a painful condition of muscle breakdown, compared with several other cholinesterase inhibitors.

Dementia is a growing problem, with almost 10 million newly diagnosed cases every year around the world, said the researchers.

"The findings of this population-based cohort study support regulatory agency warnings about the risk of donepezil-induced rhabdomyolysis," said study researcher.

The study,  looked at ICES data from 2002 to 2017 on 2,20,353 patients aged 66 years or older in Ontario, Canada, with a new prescription for donepezil, rivastigmine or galantamine, three cholinesterase inhibitors used to manage dementia and Alzheimer disease.

The researchers found that donepezil was associated with a two-fold higher risk of hospitalisation for rhabdomyolysis, a serious condition that can result in kidney disease.

According to the findings, the relative risk was small but statistically significant.

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