Saturday, February 09, 2019

No finger pricks – New breath analyser to monitor blood sugar

New hope for people with diabetes. Scientists have developed a new technology wherein a simple puff into a handheld device will be able to monitor blood sugar. The device will not only be painless, but also reusable- no finger pricks or expensive test strips.

The sensor device will work like a breath-analyzer, but rather than measuring alcohol, the sensor measures acetone to determine an individual's blood glucose level, according to the lead researcher.
" Acetone is a bio-marker for blood glucose level," explained a researcher.


Researchers began developing the sensor in 2015 through a  two-year grant .


To make the biosensor, the researchers used a technique called molecular imprinting to deposit a polymer layer onto graphene. " The 3D polymer has small cavities that are the same shape and size as acetone molecules," he said. " It works like a filter, allowing only acetone to get through and bind to the graphene".


" Human exhales breath contains more than 3,000 volatile organic compounds resulting from the body's metabolic pathways," he explained. " The sensor detects only acetone and ignores the others. The selectivity is very high".


When the acetone molecules attach to the graphene, it changes the material's electrical properties. " The amount of resistance in the graphene sensing layer changes based on the amount of acetone gas," he said. To test the sensor, he placed it in a chamber into which acetone gas was introduced for 3 seconds.


The sensor detects acetone levels ranging from 0.9 ppm to 10ppm. " The acetone concentrations in the breath of a non-diabetic range from 0.3 to 0.9 parts per million, however, in diabetes, those levels are higher," he explained. Additional electronic components will then convert the measurement to milligrams per deciliter, the standard blood glucometer reading.


Next, he will optimize the sensor's recovery time- how ling the user must wait before taking another reading. " My goal is to make it less than one minute", he said.


Once preliminary evaluations have been completed, the researchers will integrate the sensor into a prototype device that can be tested using human breath.


Researcher in-charge for commercialising project, envisions putting the breath sensor into a smartphone along with an app that enables users to effectively monitor and manage their blood glucose levels. " This new technology promises to be revolutionary".


" If we succeed, it's going to be ' wow'", he said. " This will make life easier for everyone with diabetes".


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Read more at Speciality Medical Dialogues: No finger pricks – New breath analyser to monitor blood sugar https://speciality.medicaldialogues.in/no-finger-pricks-new-breath-analyser-to-monitor-blood-sugar/
Read more at Speciality Medical Dialogues: No finger pricks – New breath analyser to monitor blood sugar https://speciality.medicaldialogues.in/no-finger-pricks-new-breath-analyser-to-monitor-blood-sugar/
Read more at Speciality Medical Dialogues: No finger pricks – New breath analyser to monitor blood sugar https://speciality.medicaldialogues.in/no-finger-pricks-new-breath-analyser-to-monitor-blood-sugar/

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