Male Birth Control Pill Offers 'Unprecedented' Study Results

Almost sixty years since the FDA approved the pill for birth control in women, a male version may finally be on the horizon. Researchers have developed a prototype male pill that appears to be safe in a month-long trial.

More attractive to many men than a long-acting injection or topical gel—both of which are in development—the prototype pill offers a “major step forward” in male contraception, a professor   and senior investigator on the study, said in a statement.

The once-daily prototype pill suppressed certain hormones to the low levels you'd expect to see with effective longer-term contraceptives, results from a study.

The prototype pill—dimethandrolone undecanoate (DMAU)—is somewhat similar to the combined female pill, which contains estrogen and a steroid hormone. Rather than estrogen, DMAU uses a male hormone like testosterone.

Currently available forms of testosterone can exit the body too quickly for use in a once-daily pill. The “undecanoate” in DMAU, however, is a long-chain fatty acid that can slow the drug’s journey out of the body, the Dr. said.

Eighty-three men took various doses of DMAU or a placebo for a month. Researchers analyzed the men’s hormones and cholesterol with blood tests at the start and end of the study. They found testosterone and two hormones needed for the production of sperm were notably suppressed in men who took the highest dose of DMAU.

While some subjects on all doses experienced mild weight gain, DMAU appeared safe. All participants passed safety tests including liver and kidney health checks.

“Despite having low levels of circulating testosterone, very few subjects reported symptoms consistent with testosterone deficiency or excess,” the Dr. said. There were no significant changes in mood or sexual function, but a minority of participants did experience decreased libido during the study. 

The Dr. has high hopes for the results, calling them “unprecedented in the development of a prototype male pill.” Longer-term studies are the next step toward a once-daily male contraceptive pill, she said.

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