Altering protein may fight colon cancer progression
Modifying shape of a protein that
controls inflammation may reduce progression of inflammatory bowel
disease and colon cancer, according to a new study that may pave the way
for therapies against the conditions.
The altered protein - IRAK-M - causes the immune system to become supercharged, clearing out the bacteria before they can do any damage.
"When we tested mice with the altered IRAK-M protein, they had less inflammation overall and remarkably less cancer," said Coy Allen, assistant professor at Virginia-Maryland College of Veterinary Medicine in the US.
The next step, he said, will be to evaluate these findings in human patients.
The researchers are also evaluating their findings in laboratory-assembled "mini-guts" - live tissue models that Allen and his team assembled by growing intestinal stem cells on petri dishes to form highly complex small intestinal and colon tissue.
"Ultimately, if we can design therapeutics to target IRAK-M, we think it could be a viable strategy for preventing inflammatory bowel disease and cancer," said Allen.
The study was published in the journal eBioMedicine.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
https://gscrochetdesigns.
https://gseasyrecipes.
https://kneereplacement-
The altered protein - IRAK-M - causes the immune system to become supercharged, clearing out the bacteria before they can do any damage.
"When we tested mice with the altered IRAK-M protein, they had less inflammation overall and remarkably less cancer," said Coy Allen, assistant professor at Virginia-Maryland College of Veterinary Medicine in the US.
The next step, he said, will be to evaluate these findings in human patients.
The researchers are also evaluating their findings in laboratory-assembled "mini-guts" - live tissue models that Allen and his team assembled by growing intestinal stem cells on petri dishes to form highly complex small intestinal and colon tissue.
"Ultimately, if we can design therapeutics to target IRAK-M, we think it could be a viable strategy for preventing inflammatory bowel disease and cancer," said Allen.
The study was published in the journal eBioMedicine.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
https://gscrochetdesigns.
https://gseasyrecipes.
https://kneereplacement-
Labels: altered, Colon cancer, controls, immune system, inflammation, inflammatory bowel disease, modifying, progression, protein-IRK-M, reduces
posted by G S Iyer at 1:38 AM
0 Comments:
Post a Comment
<< Home