Cancer cure may lie in the gut

A new study suggests that cure for cancer may be in our intestines.

An associate professor  said that if the gastrointestinal tract remains healthy and functioning, the chances of survival increase exponentially.

Recently, it was discovered a biological mechanism that preserves the gastrointestinal tracts in mice who were delivered lethal doses of chemotherapy.

The findings could revolutionize cancer therapy.

He emphasized that this had not yet been tested in humans, and right now there's no way to know if people will respond similarly.

"All tumours from different tissues and organs can be killed by high doses of chemotherapy and radiation, but the current challenge for treating the later-staged metastasised cancer is that you actually kill the host before you kill the tumour," he said.

"It's our belief that this could eventually cure later-staged metastasised cancer. People will not die from cancer, if our prediction is true.

"We cannot know this yet, but in mice it has shown promise. Years down the road, we may have a way to make humans tolerate lethal doses of chemotherapy and radiotherapy. In this way, the later-staged, metastasised cancer can be eradicated by increased doses of chemotherapy and radiation," he added.

The lab found that when certain proteins bind with a specific molecule on intestinal stem cells, it revs intestinal stem cells into overdrive for intestinal regeneration and repair in mice.

Stem cells naturally heal damaged organs and tissues, but so-called "normal" amounts of stem cells in the intestine simply cannot keep up with the wreckage left behind by the lethal doses of chemotherapy and radiation required to successfully treat late-stage tumours.

However, the phalanx of extra stem cells protect the intestine and gastrointestinal tract, which allows the ingestion of nutrients so the body can perform other critical functions and the bacterial toxins in the intestine are prevented from entering the blood circulation, he said.

In the future, if the findings are tested in humans and show promise, these factors could give human cancer patients just enough of an extra edge to survive the stronger doses of chemotherapy and radiation, until the tumour or tumours are eradicated.

He stressed that even if the findings do show promise in humans, it could take a decade or longer before an application becomes available to use on people.

In the study, 50-to-75 percent of the mice treated with the molecule survived otherwise lethal doses of chemotherapy. All of the mice that did not receive the molecule died, he said.

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