8 Common Thyroid Dysfunctions and What Causes Them
The
thyroid is a gland inside of our necks, just below the Adam’s apple (in
men), which is an incredibly important part of our endocrine (hormonal)
system that helps regulate our metabolism, manages protein synthesis,
growth and more. Of course, just because it affects mainly physiological
processes in the body doesn’t mean it ends there, as energy production
through metabolism has a profound effect on our brains.
Around
one in eight people have a thyroid disorder. Of these, a majority are
unaware they have it, and a huge majority are women. Why are women more
susceptible? Because most thyroid disorders are caused by autoimmune
diseases, which disproportionately affect women. Because thyroid
problems often have numerous nonspecific symptoms, they are very easily
misdiagnosed.
1. Hypothyroidism
Hypothyroidism
is a disorder that manifests in reduced activity in the thyroid gland.
Because one of the main functions of the thyroid is regulating
metabolism, an underactive gland causes slower metabolism. This, in
turn, may cause inexplicable weight-gain, loss of appetite,
constipation, dry and flaky skin, hair thinning, sensitivity to cold and
depression.
In
developing countries, the leading cause for hypothyroidism is a lack of
dietary iodine, while in developed countries, hypothyroidism is
typically associated with an autoimmune disease.
2. Hyperthyroidism
As
you can probably tell by the name, this condition is the opposite of
hypothyroidism and describes an overactive thyroid gland.
Unsurprisingly, the symptoms of hyperthyroidism are nearly an exact
mirror image of hypothyroidism: weight loss that is not tied to diet or
activity and paired with an increased appetite, frequent diarrhea,
irritability, confusion, an increased heartbeat, hand tremors, heat
intolerance, sleep disorders, and mood swings.
Like
hypothyroidism, the chief culprit behind hyperthyroidism are autoimmune
diseases, and so it affects females to a much greater extent than men,
but it also appears to be hereditary and can be caused by too much
iodine in the diet.
3. Goiter
Rather
than a thyroid disorder in and of itself, goiter is a symptom of other
thyroid diseases. Goiter is a swelling of the neck due to an enlarged
thyroid gland which can be caused by any thyroid disorder, but not
having goiter doesn’t rule out a thyroid disorder.
It
can present itself as a slight swelling of the neck, as a
grapefruit-size globular swelling, or as several smaller balls in the
neck. Goiter is typically painless, but a large goiter can make eating
and breathing difficult.
Thyroid
storm is a rare and life-threatening complication of an overactive
thyroid (hyperthyroidism), which causes high fever, vomiting, and
hypertension in early stages, followed by dramatically low blood
pressure and circulatory shock in later stages. Thyroid storm could
result in heart failure or heart attack.
Thyroid
storm could be triggered by any number of conditions that aren’t
related to the thyroid, such as blood poisoning, fever, dehydration and
more. People are at larger risk of a thyroid storm if they leave their
hyperthyroidism untreated or if they discontinue their hyperthyroidism
treatment.
5. Hashimoto’s disease
Perhaps
the leading cause of hypothyroidism in the west is Hashimoto’s disease,
an autoimmune disease that causes the immune system to actively attack
the thyroid gland. Though this may cause swelling in the thyroid (and
goiter as a result), the overall effect is a gradual shrinking of the
thyroid until its destruction.
As
an autoimmune disease, Hashimoto’s disease is more common among people
who suffer from other autoimmune diseases, specifically type 1 diabetes,
celiac disease, vitiligo, and alopecia, but it is also genetic and
could be inherited.
6. Graves’ Disease
Another
autoimmune disease, Graves’ is the most common cause behind
hyperthyroidism and can be initially triggered by stress, infection or
childbirth. Additional symptoms of Graves’ are discolored, swollen shins
with lesions or nodules, as well as eyes that bulge out.
Much
like Hashimoto’s, people suffering from a preexisting autoimmune
disease are more likely to develop Graves’ disease, and conversely,
those with Graves’ are more likely to develop unrelated autoimmune
conditions. There also appears to be a genetic factor.
7. Thyroid nodules
The
most common thyroid problem and the cause of the least concern are
nodules in the thyroid gland. These can be asymptomatic and
imperceptibly small or present as lumps in the throat. In the case of
goiter, one or more lumps are indicative of nodules. Only 5% of thyroid
nodules are malign.
Problems
swallowing or speaking and a hard, immobile lump are more indicative of
malignancy, while a family history of autoimmune diseases and thyroid
conditions accompanied by a nodule that is soft and painful are all
signs of the nodule being benign.
Thyroid
nodules are extremely common, with about 50% of people having a nodule
at some point in their life. Other thyroid conditions, such as
Hashimoto’s and Graves’ will often cause nodules as well.
8. Thyroid cancer
Most
types of thyroid cancer have an excellent prognosis and are very
manageable, as they do not tend to metastasize. Though not overly
common, diagnosed cases are on the rise, but that may very well be due
to better detection, rather than the cancer being on the rise.
The
lack of detection in the past may be due to a lack of complaints from
patients, who did not realize something was wrong to begin with. There
are four types of thyroid cancer:
- Papillary
- Follicular
- Medullary
- Anaplastic.
Of
those, only anaplastic thyroid cancer, which is an extremely rare,
fast-acting and metastasizing type of cancer, is of great concern. For
the other three types of cancer, the survival rate over five years is
90% and 84% over ten years.
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Labels: anaplastic, follicular phase length, goiter, Graves' disease, Hashimoto's, hyperthyroidism, Hypothyroidism, medullary thyroid cancers, nodules, papillary, thyroid cancer, thyroid dysfunctions
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