Researchers discover new blood test which can detect multiple types of cancer
Researchers have discovered a new kind of blood test in development which is capable of screening for a number of types of cancer.
Moreover, it has a high degree of accuracy, according to the results presented at the recently held seminar.
The test, developed uses next-generation sequencing technology to probe DNA for tiny chemical tags ( methylation) that influence whether genes are active or inactive.
When applied to nearly 3,600 blood samples, some from patients with cancer, some from people who had not been diagnosed with cancer at the time of the blood draw- the test successfully picked up a cancer signal from the cancer patient samples and correctly identified the tissue from where cancer began ( the tissue of origin).
The test's specificity- its ability to return a positive result only when cancer is actually present- was high, as was its ability to pinpoint the organ or tissue of origin researchers found.
The new test looks for DNA, which cancer cells shed into the blood stream when they die. In contrast to ' liquid biopsies', which detest genetic mutations or other cancer-related alterations in DNA, the technology focuses on modifications to DNA known as methyl groups.
Methyl groups are chemical units that can be attached to DNA, in a process called methylation, to control which genes are 'on' and which are ' off'.
Abnormal patterns of methylation turn out to be, in many cases, more indicative of cancer- and cancer type- than mutations are.
The new test zeroes in on portions of the genome where abnormal methylation patterns are found in cancer cells.
Our previous work indicated that methylation-based assays outperform traditional DNA-sequencing approaches to detecting multiple forms of cancer in blood samples, said the study's lead author.
In the study, investigators analysed cell-free DNA ( DNA that had once been confined to cells but had entered the bloodstream upon the cells' death) in 3,583 blood samples, including 1,530 from patients diagnosed with cancer and 2,053 from people without cancer.
The patients samples comprised more than 20 types of cancer, including hormone receptor-negative breast, colorectal, esophageal, gallbladder, gastric, head and neck, lung, lymphoid leukemia, multiple myeloma, ovarian and pancreatic cancer.
The overall specificity was 99.4 %, meaning only 0.6% of the results incorrectly indicated that cancer was present.
The sensitivity of the assay for detecting pre-specified high mortality cancer ( the percent of blood samples from these patients that tested positive for cancer) was 76 %.
Within this group, the sensitivity was 32 % for patients with stage 1 cancer, 76 % for those with stage 2 , 85 % for stage 3 and 93 % for stage 4.
Sensitivity across all cancer types was 55%, with similar increases in detection by stage. For the 97 % of samples that returned a tissue of origin result, the test correctly identified the organ or tissue of origin in 89 % of cases.
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Moreover, it has a high degree of accuracy, according to the results presented at the recently held seminar.
The test, developed uses next-generation sequencing technology to probe DNA for tiny chemical tags ( methylation) that influence whether genes are active or inactive.
When applied to nearly 3,600 blood samples, some from patients with cancer, some from people who had not been diagnosed with cancer at the time of the blood draw- the test successfully picked up a cancer signal from the cancer patient samples and correctly identified the tissue from where cancer began ( the tissue of origin).
The test's specificity- its ability to return a positive result only when cancer is actually present- was high, as was its ability to pinpoint the organ or tissue of origin researchers found.
The new test looks for DNA, which cancer cells shed into the blood stream when they die. In contrast to ' liquid biopsies', which detest genetic mutations or other cancer-related alterations in DNA, the technology focuses on modifications to DNA known as methyl groups.
Methyl groups are chemical units that can be attached to DNA, in a process called methylation, to control which genes are 'on' and which are ' off'.
Abnormal patterns of methylation turn out to be, in many cases, more indicative of cancer- and cancer type- than mutations are.
The new test zeroes in on portions of the genome where abnormal methylation patterns are found in cancer cells.
Our previous work indicated that methylation-based assays outperform traditional DNA-sequencing approaches to detecting multiple forms of cancer in blood samples, said the study's lead author.
In the study, investigators analysed cell-free DNA ( DNA that had once been confined to cells but had entered the bloodstream upon the cells' death) in 3,583 blood samples, including 1,530 from patients diagnosed with cancer and 2,053 from people without cancer.
The patients samples comprised more than 20 types of cancer, including hormone receptor-negative breast, colorectal, esophageal, gallbladder, gastric, head and neck, lung, lymphoid leukemia, multiple myeloma, ovarian and pancreatic cancer.
The overall specificity was 99.4 %, meaning only 0.6% of the results incorrectly indicated that cancer was present.
The sensitivity of the assay for detecting pre-specified high mortality cancer ( the percent of blood samples from these patients that tested positive for cancer) was 76 %.
Within this group, the sensitivity was 32 % for patients with stage 1 cancer, 76 % for those with stage 2 , 85 % for stage 3 and 93 % for stage 4.
Sensitivity across all cancer types was 55%, with similar increases in detection by stage. For the 97 % of samples that returned a tissue of origin result, the test correctly identified the organ or tissue of origin in 89 % of cases.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
https://gscrochetdesigns.blogspot.com. one can see my crochet creations
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
Labels: different types of cancer, identified, new blood test, next-gen sequencing tech., origin of cancer, probes DNA, screening, tiny chemical tags, tissue
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