This gene could reduce brain swelling after stroke
Researchers have found that a dose of the TRIM9 gene could facilitate the brain-healing after a stroke Also, the gene could reduce the damage caused in concussion and encephalitis as well.
The study published described a key gene, TRIM9, involved with compressing inflammation in the brain, as well as what happens when the injured brain gets an added boost of that gene.
When a person has a stroke, the brain responds with inflammation, which expands the area of injury and leads to more disability.
The gene, TRIM9, is abundant in the youthful brain but grows scarce with age, just when people become more at risk from stroke.
In a lab model of stroke, researchers found that older brains with low TRIM9 levels, or engineered brains missing the TRIM9 gene entirely, were prone to extensive swelling following a stroke.
But when the scientists used a harmless a virus to carry a dose of the gene directly into TRIM9-deficient brains, the swelling decreased dramatically and recovery improved.
The lead author of the study said, it's unlikely that genetherapy delivered by viruses will become the go-to treatment for strokes, head injuries or encephalitis. It's too slow and the best shot at treating stroke is within the first 30 minutes to one hour.
The author informed that the nest step will be indentifying what exactly flips on the switch for TRIM9 expression.
Maybe there will be a way to chemically activate TRIM( right after a stroke. Or may be a football player can take a medication that turns on TRIM9 gene expression right after they get a blow to the head, the author added.
Not all information in the brain is bad, the author added. Inflammation plays a role in fighting infection and helps clear away dead tissue.
But when it goes on too long, neurons die, inflammation causes the brain's blood vessels to become permeable, allowing white blood cells to enter tissue where they don't belong.
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The study published described a key gene, TRIM9, involved with compressing inflammation in the brain, as well as what happens when the injured brain gets an added boost of that gene.
When a person has a stroke, the brain responds with inflammation, which expands the area of injury and leads to more disability.
The gene, TRIM9, is abundant in the youthful brain but grows scarce with age, just when people become more at risk from stroke.
In a lab model of stroke, researchers found that older brains with low TRIM9 levels, or engineered brains missing the TRIM9 gene entirely, were prone to extensive swelling following a stroke.
But when the scientists used a harmless a virus to carry a dose of the gene directly into TRIM9-deficient brains, the swelling decreased dramatically and recovery improved.
The lead author of the study said, it's unlikely that genetherapy delivered by viruses will become the go-to treatment for strokes, head injuries or encephalitis. It's too slow and the best shot at treating stroke is within the first 30 minutes to one hour.
The author informed that the nest step will be indentifying what exactly flips on the switch for TRIM9 expression.
Maybe there will be a way to chemically activate TRIM( right after a stroke. Or may be a football player can take a medication that turns on TRIM9 gene expression right after they get a blow to the head, the author added.
Not all information in the brain is bad, the author added. Inflammation plays a role in fighting infection and helps clear away dead tissue.
But when it goes on too long, neurons die, inflammation causes the brain's blood vessels to become permeable, allowing white blood cells to enter tissue where they don't belong.
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Labels: Brain, brain-healing, brain's blood vessels, chemically activate, compressing inflammation, engineered, extensive swelling, head injury, injury, neurons die, permeable, stroke, TRIM9 gene, white blood cells
posted by G S Iyer at 4:25 AM
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