Lupus strongly linked to imbalances in gut microbiome
According to a new study, systemic lupus erythematosus (SLE) is linked to an abnormal
mix of bacteria in the gut.
The disease is marked by the attack on joints, skin, and kidneys by the body’s immune system.
The authors of the current study say their experiments are the first detailed evidence of a link between bacterial imbalances in the gut and potentially life-threatening forms of SLE.
The new study, showed that 61 women diagnosed with SLE had roughly five times more gut bacteria known as Ruminococcus gnavus, than 17 women of similar ages and racial backgrounds who did not have the disease and were healthy. Lupus is more common in women than in men.
Study results further showed that disease “flares,” which can range from instances of skin rash and joint pain to severe kidney dysfunction requiring dialysis, closely tracked major increases in R. gnavus bacterial growth in the gut, alongside the presence in blood samples of immune proteins called antibodies, specifically shaped to attach to the bacteria.
Study participants with kidney flares had especially high levels of antibodies to R. gnavus.
Senior study author said, “Our study strongly suggests that in some patients bacterial imbalances may be driving lupus and its associated disease flares,” adding, “Our results also point to leakages of bacteria from the gut as a possible immune system trigger of the disease, and suggest that the internal gut environment may therefore play a more critical role than genetics in renal flares of this all too often fatal disease.” He also suspects that antibodies to R. gnavus provoke a “continuous and unrelenting” immune attack on organs involved in flares.
He added that the study could prompt the development of relatively simple blood tests to detect antibodies to leaked bacteria, which in turn could also be used to diagnose and track lupus progression and therapy, even in the disease’s earliest stages.
He, however, cautions that larger studies are needed to confirm how these bacteria may cause lupus. But if future experiments show similarly positive results, then it could result in shifts from current approaches to treating the disease, which focus on immune-suppressing anticancer medications to relieve symptoms and injury to the kidneys.
The disease is marked by the attack on joints, skin, and kidneys by the body’s immune system.
The authors of the current study say their experiments are the first detailed evidence of a link between bacterial imbalances in the gut and potentially life-threatening forms of SLE.
The new study, showed that 61 women diagnosed with SLE had roughly five times more gut bacteria known as Ruminococcus gnavus, than 17 women of similar ages and racial backgrounds who did not have the disease and were healthy. Lupus is more common in women than in men.
Study results further showed that disease “flares,” which can range from instances of skin rash and joint pain to severe kidney dysfunction requiring dialysis, closely tracked major increases in R. gnavus bacterial growth in the gut, alongside the presence in blood samples of immune proteins called antibodies, specifically shaped to attach to the bacteria.
Study participants with kidney flares had especially high levels of antibodies to R. gnavus.
Senior study author said, “Our study strongly suggests that in some patients bacterial imbalances may be driving lupus and its associated disease flares,” adding, “Our results also point to leakages of bacteria from the gut as a possible immune system trigger of the disease, and suggest that the internal gut environment may therefore play a more critical role than genetics in renal flares of this all too often fatal disease.” He also suspects that antibodies to R. gnavus provoke a “continuous and unrelenting” immune attack on organs involved in flares.
He added that the study could prompt the development of relatively simple blood tests to detect antibodies to leaked bacteria, which in turn could also be used to diagnose and track lupus progression and therapy, even in the disease’s earliest stages.
He, however, cautions that larger studies are needed to confirm how these bacteria may cause lupus. But if future experiments show similarly positive results, then it could result in shifts from current approaches to treating the disease, which focus on immune-suppressing anticancer medications to relieve symptoms and injury to the kidneys.
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE
HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.
PS-
THOSE INTERESTED IN
RECIPES ARE FREE TO VIEW MY BLOG-
https://gseasyrecipes.blogspot.com/
FOR INFO ABOUT KNEE
REPLACEMENT, YOU CAN VIEW MY BLOG-
https:// kneereplacement-stickclub.blogspot.com/
FOR CROCHET DESIGNS https://gscrochetdesigns.blogspot.com
Labels: antibodies, attack on joints, dialysis, gut microbiome, imbalances, immune system, linked to, lupus, severe kidney dysfunction, skin and kidneys, skin rashes
posted by G S Iyer at 9:48 AM
0 Comments:
Post a Comment
<< Home