Novel treatment found for disfiguring cutaneous sarcoidosis
A new study has reported successful treatment of a patient with disfiguring sarcoidosis with a drug approved for rheumatoid arthritis.
For several months, a 48 year old, female patient, was treated with arthritis medication tofacitinib, a Jak inhibitor, which blocks a pathway known as Jak-STAT, twice daily. The patient with cutaneous sarcoidosis had not previously had a response to medications and had not received systemic gluco-corticoids. The researchers observes that her skin lesions nearly disappeared. This treatment resulted in clinical and histologic remission of her skin disease. They also performed RNA sequencing on biopsied skin from the patient before and during treatment.
The researcher has pioneered the use of Jak inhibitors to treat other intractable skin diseases, including vitiligo, alopecia areata and eczema.
A frequently awful disease, which to date has no reliably effective therapy, may now be targeted with Jak inhibitors. We've a relatively safe medicine that works. Before treatment, we're able to show that the Jak-STAT pathway is activated, he said.
During treatment, not only does her skin disease go away, but there is no activation of the pathway, he added.
We plan to evaluate the activation of the Jak-STAT pathway in the lung fluid and blood of over 200 patients with pulmonary and multi-organ sarcoidosis, said co-author. These big steps toward understanding a disease that has been a mystery for years, the researchers said. Sarcoidosis is an inflammatory disease that affects multiple organs in the body. While some sarcoidosis patients recover without treatment, others suffer damage to the lungs, heart, lymph nodes,skin and other organs. Current treatments, including steroids, are not reliably effective for the skin and can cause serious side effects.
For several months, a 48 year old, female patient, was treated with arthritis medication tofacitinib, a Jak inhibitor, which blocks a pathway known as Jak-STAT, twice daily. The patient with cutaneous sarcoidosis had not previously had a response to medications and had not received systemic gluco-corticoids. The researchers observes that her skin lesions nearly disappeared. This treatment resulted in clinical and histologic remission of her skin disease. They also performed RNA sequencing on biopsied skin from the patient before and during treatment.
The researcher has pioneered the use of Jak inhibitors to treat other intractable skin diseases, including vitiligo, alopecia areata and eczema.
A frequently awful disease, which to date has no reliably effective therapy, may now be targeted with Jak inhibitors. We've a relatively safe medicine that works. Before treatment, we're able to show that the Jak-STAT pathway is activated, he said.
During treatment, not only does her skin disease go away, but there is no activation of the pathway, he added.
We plan to evaluate the activation of the Jak-STAT pathway in the lung fluid and blood of over 200 patients with pulmonary and multi-organ sarcoidosis, said co-author. These big steps toward understanding a disease that has been a mystery for years, the researchers said. Sarcoidosis is an inflammatory disease that affects multiple organs in the body. While some sarcoidosis patients recover without treatment, others suffer damage to the lungs, heart, lymph nodes,skin and other organs. Current treatments, including steroids, are not reliably effective for the skin and can cause serious side effects.
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Read more at Speciality Medical Dialogues: Novel treatment found for disfiguring cutaneous sarcoidosis https://speciality.medicaldialogues.in/novel-treatment-found-for-disfiguring-cutaneous-sarcoidosis/
Labels: cutaneous, disfiguring, gluco-corticoids, histologic, inflammatory diseases, Jak-STAT, Jal inhibitor, multiorgan, pulmonary, remissions, rheumatoid arthritis, sarcoidosis
posted by G S Iyer at 9:41 AM
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