Advanced MRI detect placental perfusion abnormalities in pregnancies complicated by fetal CHD

In pregnancies complicated by fetal congenital heart disease (CHD), global placental perfusion was significantly decreased and regional variation of placental perfusion significantly increased as pregnancies progressed, findings that point to non-invasive imaging providing an early warning of placental dysfunction. A Children’s National Health System research team is thought to be the first to report non-invasive, whole placenta perfusion imaging in utero in a study.
 
According to the researchers, congenital heart defects are the most common type of birth defect, affecting 8 in 1,000 newborns. Early in pregnancy, the fetal heart follows a parallel developmental course as the placenta, which supplies the growing fetus with oxygen and nutrients while ferrying out waste products. The study authors write that placental arteries are dynamic during pregnancy, remodeling themselves to accommodate increased blood flow as fetuses undergo explosive growth spurts in later stages of pregnancy. If this crucial remodeling does not occur, the placenta may not supply sufficient oxygen and nutrients to the fetus, leading to fetal growth restriction or preeclampsia.

The research team, enrolled 48 pregnant women who underwent at least one fetal magnetic resonance imaging (MRI) session during their second or third trimester of pregnancy. Thirty-one of the women were healthy volunteers whose mean gestational age was 30 weeks (range: 21 to 39 gestational weeks). Seventeen women were pregnant with fetuses diagnosed with CHD whose mean gestational age was 32 weeks (range: 22 to 38 gestational weeks).

The researchers used velocity-selective arterial spin labeling (VSASL), a powerful MRI technique that directly measures the rate of delivery of arterial blood to organs like the brain. ASL tracks water molecules within the blood as blood flows through arteries, eliminating the need to use a contrast agent. The team was able to distinguish the placenta perfusion contributions by the fetus and the mother.

“In pregnancies complicated by fetal CHD, global placental perfusion significantly decreased and regional variation of placental perfusion significantly increased with advancing gestational age,” says  the study’s lead author.

“Just like the human brain, heart and kidneys—organs that can commandeer heightened blood flow when needed—the placenta may employ an auto-regulatory mechanism to optimize perfusion,” adds  the study’s senior author. “The early increased global placental profusion in pregnancies complicated by CHD may represent an attempt to correct for insufficient fetal blood flow.”

The research team writes that the findings demonstrate that placental dysfunction due to CHD can be apparent as early as the second trimester of pregnancy using this imaging technology.

“The predictive value of VSASL imaging, which we continue to study, holds the promise of detecting dysfunction before placental abnormalities become irreversible,” the author says. 

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.    
 
PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-                      

HTTP:GSEASYRECIPES.BLOGSPOT.COM/
FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                       

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/
FOR CROCHET DESIGNS
HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM