Poliovirus destroys cancer cells and stops tumor regrowth
Researchers have
modified poliovirus to attack cancer tumors. The modified virus appears
to unleash the body’s own capacity to fight malignancies by activating
an inflammation process that counter’s the ability of cancer cells to
evade the immune system.
Their research provides the first insight into the workings of a therapy that has shown promise in early clinical trials in patients with recurrent glioblastoma, a lethal form of brain cancer. The modified poliovirus received a breakthrough therapy designation.
“We have had a general understanding of how the modified poliovirus works, but not the mechanistic details at this level,” said co-senior author who developed the therapy. “This is hugely important to us. Knowing the steps that occur to generate an immune response will enable us to rationally decide whether and what other therapies make sense in combination with poliovirus to improve patient survival.”
The research team elucidated how the poliovirus works not only to attack cancer cells directly, but also to trigger a longer-lasting immune response that appears to inhibit regrowth of the tumor.
Using human melanoma and breast cancer cell lines, and then validating the findings in mouse models, the researchers found that the modified poliovirus therapy starts by attaching to malignant cells, which have an abundance of CD155 protein. The CD155 protein is otherwise known as the poliovirus receptor. The modified virus then begins to attack the tumor cells, directly killing many, but not all. This releases tumor antigens.
The second phase of assault is more complicated. By killing the cancer cells, the modified poliovirus triggers an alarm within the immune system, alerting the body’s defenses to go on the attack.
Not only is poliovirus killing tumor cells, it is also infecting the antigen-presenting cells, which allows them to function in such a way that they can now raise a T-cell response that can recognize and infiltrate a tumor,” Dr. said. “This is an encouraging finding, because it means the poliovirus stimulates an innate inflammatory response.”
Their research provides the first insight into the workings of a therapy that has shown promise in early clinical trials in patients with recurrent glioblastoma, a lethal form of brain cancer. The modified poliovirus received a breakthrough therapy designation.
“We have had a general understanding of how the modified poliovirus works, but not the mechanistic details at this level,” said co-senior author who developed the therapy. “This is hugely important to us. Knowing the steps that occur to generate an immune response will enable us to rationally decide whether and what other therapies make sense in combination with poliovirus to improve patient survival.”
The research team elucidated how the poliovirus works not only to attack cancer cells directly, but also to trigger a longer-lasting immune response that appears to inhibit regrowth of the tumor.
Using human melanoma and breast cancer cell lines, and then validating the findings in mouse models, the researchers found that the modified poliovirus therapy starts by attaching to malignant cells, which have an abundance of CD155 protein. The CD155 protein is otherwise known as the poliovirus receptor. The modified virus then begins to attack the tumor cells, directly killing many, but not all. This releases tumor antigens.
The second phase of assault is more complicated. By killing the cancer cells, the modified poliovirus triggers an alarm within the immune system, alerting the body’s defenses to go on the attack.
Not only is poliovirus killing tumor cells, it is also infecting the antigen-presenting cells, which allows them to function in such a way that they can now raise a T-cell response that can recognize and infiltrate a tumor,” Dr. said. “This is an encouraging finding, because it means the poliovirus stimulates an innate inflammatory response.”
The researchers will conduct further studies to focus on the additional immune activity following exposure to the modified virus. THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES. PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-
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Labels: alerts defense cells, antigens, Cancer Cells, CD155 protein, destroys, immune system, polio virus, stops tumour growth
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