Vitamin C, antibiotics combined are 100 times more powerful at killing cancer
A combination of vitamin C and antibiotics may be up to 100 times
more effective at killing cancer cells than standard drugs, says new
research.
Researchers said cancer stem cells, which fuel the growth of fatal tumours, can be knocked out by a one-two combination of antibiotics and vitamin C.
The antibiotic, doxycycline, followed by doses of ascorbic acid (vitamin C), were surprisingly effective in killing the cancer stem cells under laboratory conditions.
The researchers said their method offers a new explanation for
how to prevent cancer cells from becoming treatment-resistant and how
combinations therapies can be developed to overcome drug resistance.
The team showed that vitamin C was up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, but they say that when vitamin C is combined with an antibiotic, it is up to ten times more effective, making it nearly 100 times more effective than 2-DG.
As doxycycline and vitamin C are both relatively non- toxic, this could dramatically reduce the possible side- effects of anti-cancer therapy, researchers said.
“Certain cancer cells which we call metabolically flexible are able to switch their fuel source,” said a professor. “Thus, when the drug treatment reduces the availability of a particular nutrient, the flexible cancer cells can feed themselves with an alternative energy source,” said the Prof..
The new combination approach prevents cancer cells from changing their diet (metabolically inflexible), and effectively starves them, by preventing them from using any other available types of bio-fuels.
The
team added doxycycline in ever increasing doses over a three-month
period, to induce metabolic inflexibility. The result was to leave the
cancer cells alive, but severely attenuated and depleted, so that they
would be much more susceptible to starvation, by a second metabolic
“punch”.
First, the researchers inhibited the tumour cell mitochondria, by restricting the cancer cells only to glucose as a fuel source; then, they took away their glucose, effectively starving the cancer cells to death.
“In this scenario, vitamin C behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the ‘powerhouse’ of the cell,” said the co-author of the study.
The team also identified eight other drugs that could be used as a “second-punch” after the antibiotic regime, including berberine (a natural product) and a number of cheap non-toxic approved drugs.
“This is further evidence that vitamin C and other non- toxic compounds may have a role to play in the fight against cancer,” Prof. said.
“Our results indicate it is a promising agent for clinical trials, and as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis,” he said.
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Researchers said cancer stem cells, which fuel the growth of fatal tumours, can be knocked out by a one-two combination of antibiotics and vitamin C.
The antibiotic, doxycycline, followed by doses of ascorbic acid (vitamin C), were surprisingly effective in killing the cancer stem cells under laboratory conditions.
The team showed that vitamin C was up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, but they say that when vitamin C is combined with an antibiotic, it is up to ten times more effective, making it nearly 100 times more effective than 2-DG.
As doxycycline and vitamin C are both relatively non- toxic, this could dramatically reduce the possible side- effects of anti-cancer therapy, researchers said.
“Certain cancer cells which we call metabolically flexible are able to switch their fuel source,” said a professor. “Thus, when the drug treatment reduces the availability of a particular nutrient, the flexible cancer cells can feed themselves with an alternative energy source,” said the Prof..
The new combination approach prevents cancer cells from changing their diet (metabolically inflexible), and effectively starves them, by preventing them from using any other available types of bio-fuels.
First, the researchers inhibited the tumour cell mitochondria, by restricting the cancer cells only to glucose as a fuel source; then, they took away their glucose, effectively starving the cancer cells to death.
“In this scenario, vitamin C behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the ‘powerhouse’ of the cell,” said the co-author of the study.
The team also identified eight other drugs that could be used as a “second-punch” after the antibiotic regime, including berberine (a natural product) and a number of cheap non-toxic approved drugs.
“This is further evidence that vitamin C and other non- toxic compounds may have a role to play in the fight against cancer,” Prof. said.
“Our results indicate it is a promising agent for clinical trials, and as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis,” he said.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
https://gscrochetdesigns.blogspot.com. one can see my crochet creations
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
Labels: anti-cancer therapy, antibiotics, ascorbic acid, doxycycline, killing cancer cells, non-toxic, powerful, reduce, side-effects, Vitamin C
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