New antibody to block both pain and itching

Scientists have discovered an antibody that simultaneously blocks the sensations of pain and itching in studies with mice.

The new antibody found by Duke University researchers works by targeting the voltage-sensitive sodium channels in the cell membrane of neurons.

Voltage-sensitive sodium channels control the flow of sodium ions through the neuron's membrane. One particular type of sodium channel, called the Nav1.7 subtype, is responsible for sensing pain.
Mutations in the human gene encoding the Nav1.7 sodium channel can lead to either the inability to sense pain or pain hypersensitivity.

These mutations do not affect other sensations such as touch or temperature. Hence, the Nav1.7 sodium channel might be a very specific target for treating pain disorders without perturbing the patients' ability to feel other sensations.

"Originally, I was interested in isolating these sodium channels from cells to study their structure," said Seok-Yong Lee, principal investigator of the study.

He designed antibodies that would capture the sodium channels so that he could study them.
"The channel is off when it is closed. Since the antibody stabilises the closed state, the channel becomes less sensitive to pain," said Lee.

If this held true in live animals, then the animals would also be less sensitive to pain.

To test this idea, Lee sought the help of Ru-Rong Ji, an expert in the study of pain and itch sensation.
Using laboratory mouse models of inflammatory and neuropathic pain, they showed that the antibody can target the Nav1.7 channel and reduce the pain sensation in these mice.

More importantly, mice receiving the treatment did not show signs of physical dependence or enhanced tolerance towards the antibody.

"Pain and itch are distinct sensations, and pain is often known to suppress itch," said Ji.

The team found that the antibody can also relieve acute and chronic itch in mouse models, making them the first to discover the role of Nav1.7 in transmitting the itch sensation.

"Now we have a compound that can potentially treat both pain and itch at the same time," said Lee. Both of these symptoms are common in allergic contact dermatitis.

The team is pursuing a patent for the antibody.

"We hope our discovery will garner interest from pharmaceutical companies that can help us expand our studies into clinical trials," Lee said.

The finding appears in the journal Cell.

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