Coriander helps to fight Arthritis
A study has found that coriander plays a significant therapeutic role in managing rheumatoid arthritis (RA). Coriander was found to inhibit joint swelling & prevent the progression of the disease among adult albino rats.
Arthritis is basically an inflammation of the joints. This swelling is triggered by the release of some mediator substances known as pro-inflammatory cytokines. The researchers have found that extracts of coriander seeds prevent the release of these mediators in the body.
The researchers have suggested that in comparison to steroids, which operate as anti-inflammatory agents, the herb's action against the mediator substances could make it a "disease modifier".
Non-steroid anti-inflammatory drugs (NSAIDs), though effective in reducing articular & periarticular inflammation, are less effective in attenuating disease progression. coriander was also found to have steroid like characteristics, as it helped in reducing inflammation far better than standard drugs.
the coriander seeds were ground & the powdered extract was administered to the rats in the experiment group. after dividing the rats into 5 groups, their ankle joint diameter was measured before the study. the control group received standard arthritis medications ( steroids), & the experimental group was given the seed extract. Arthritis was induced by injecting formaldehyde solution into the left hind paw of all animals. In the following 28 days, the swelling of the ankle joint was constantly measured.
The group which was given the coriander seed extract showed far better decline in inflammation, & produced quicker results. While the reduction in the experimental group was 32 mg per kg of body weight of the rat, the control groups only showed reductions from the 9th & 10th days, at a rate of 16 mg per kg of body weight.
The level of the mediators which produce cytokines showed significant decline on administration of coriander while the groups which got standard drugs had no variations at these levels.
The plant extract could be explored to be developed as a disease modifying agent in the treatment of rheumatoid arthritis, the researchers felt. The toxicity reports showed no side effects of coriander seed extract.
Arthritis is basically an inflammation of the joints. This swelling is triggered by the release of some mediator substances known as pro-inflammatory cytokines. The researchers have found that extracts of coriander seeds prevent the release of these mediators in the body.
The researchers have suggested that in comparison to steroids, which operate as anti-inflammatory agents, the herb's action against the mediator substances could make it a "disease modifier".
Non-steroid anti-inflammatory drugs (NSAIDs), though effective in reducing articular & periarticular inflammation, are less effective in attenuating disease progression. coriander was also found to have steroid like characteristics, as it helped in reducing inflammation far better than standard drugs.
the coriander seeds were ground & the powdered extract was administered to the rats in the experiment group. after dividing the rats into 5 groups, their ankle joint diameter was measured before the study. the control group received standard arthritis medications ( steroids), & the experimental group was given the seed extract. Arthritis was induced by injecting formaldehyde solution into the left hind paw of all animals. In the following 28 days, the swelling of the ankle joint was constantly measured.
The group which was given the coriander seed extract showed far better decline in inflammation, & produced quicker results. While the reduction in the experimental group was 32 mg per kg of body weight of the rat, the control groups only showed reductions from the 9th & 10th days, at a rate of 16 mg per kg of body weight.
The level of the mediators which produce cytokines showed significant decline on administration of coriander while the groups which got standard drugs had no variations at these levels.
The plant extract could be explored to be developed as a disease modifying agent in the treatment of rheumatoid arthritis, the researchers felt. The toxicity reports showed no side effects of coriander seed extract.
Labels: Coriander seeds, inflammation, rheumatoid arthritis
posted by G S Iyer at 8:14 AM
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