New accurate, non invasive method for blood sugar estimation developed

Researchers have developed a new accurate metabolic heat conformation (MHC) method, for the noninvasive measurement of blood sugar. The new method can be used in non-thermal equilibrium states also like after food. The research was presented at meeting of American Diabetic Association.

A traditional non-invasive blood sugar measurement system based on the method of metabolic heat conformation (MHC) consists of three temperature sensors, two humidity sensors, an infrared sensor and an optical measurement device. The blood sugar level can be deduced from the quantity of heat dissipation, blood flow rate of local tissue and degree of blood oxygen saturation.

The traditional metabolic heat conformation (MHC) method can be used for non-invasive blood sugar measurements when the body is in thermal equilibrium state. But in non-thermal equilibrium state, such as after meals, the traditional method may result in a poor accuracy.

Hock Tan and Zonyang HE at Novanex Inc. North Brunswick, New Jersey, United States have proposed a new method by extending the MHC principle to cover non-equilibrium state and develop a new measurement standard and calculation algorithm.

Results from new clinical trials using this new method show significant improvement in accuracy of blood sugar measurements. The blood sugar measurement for the new algorithm is the sum of the blood sugar in equilibrium state and the blood sugar increase in non-equilibrium state.

Results from clinical trials using this new method show significant

improvement in accuracy of blood sugar measurements. Compared

with the traditional MHC method, measurements using the new

method results in improvement in correlation coefficients with

intravenous blood-draw glucose concentration from 0.71 to 0.93 (for

fasting measurements), from 0.61 to 0.93 (for measurements of 2

hours after a meal) and from 0.63 to 0.89 (for measurements of 3.5

hours after a meal). Applying Parkes Error Standard analysis, in the

traditional MHC method, Range A (relative error does not exceed

±20%) accounts only for 54.3%, Range B (relative error does not

exceed ±50%) accounts for 39.6%. In the new method, Range A

accounts for 81.1%, and Range B accounts for 16.2%.

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