Nano-sized cells of body may help in fighting cancer
The nano-sized cells that transfer genetic material to other cells in our body may turn into mini treatment to kill cancer cells, suggests a study.
What we've done is improve a therapeutic approach to delivering enzyme-producing genes that can convert certain drugs into toxic agents and target tumors, said the lead author of the study.
These drugs, or pro-drugs, start out as inactive compounds. But once they metabolise in the body, they're immediately activated and can get to work in fighting everything from cancer to headache. Aspirin is an example of pro-drug.
In this case, researchers used extracellular vesicles, or EVs, to deliver the enzyme-producing genes that could activate a prodrug combination therapy of ganciclovir and CB1954 in breast cancer cells.
Mini circle DNA and regular plasmid-- 2 different gene vectors that act as additional delivery mechanisms for DNA--were loaded into the vesicles to see which was better at helping transport treatment. This is known as a gene-directed enzyme, pro-drug therapy.
They found that the mini circle DNA was 14 times more effective at delivery and even more successful at killing the cancerous tumour.
Interestingly, the plasmid delivery method didn't show any tumour cell killing, the Dr. said. Yet the mini circle DNA therapy killed more than half of the breast cancer cells in the mice.
According to the researcher, this new approach could effectively become a better cancer treatment option than chemotherapy down the road.
Conventional chemotherapy isn't able to differentiate between tumours and normal tissue, so it attacks it all, he said. This non-specificity can cause severe side effects and insufficient drug concentration in tumours.
With EVs, treatment can be targeted and because of their compatibility with the human body, this type of delivery could minimise the risk of unwanted immune responses that can come with other gene therapies.
If EVs prove to be effective in humans, it would be an ideal platform for gene delivery and it could be used in humans sooner than we expect, the researcher said.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
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What we've done is improve a therapeutic approach to delivering enzyme-producing genes that can convert certain drugs into toxic agents and target tumors, said the lead author of the study.
These drugs, or pro-drugs, start out as inactive compounds. But once they metabolise in the body, they're immediately activated and can get to work in fighting everything from cancer to headache. Aspirin is an example of pro-drug.
In this case, researchers used extracellular vesicles, or EVs, to deliver the enzyme-producing genes that could activate a prodrug combination therapy of ganciclovir and CB1954 in breast cancer cells.
Mini circle DNA and regular plasmid-- 2 different gene vectors that act as additional delivery mechanisms for DNA--were loaded into the vesicles to see which was better at helping transport treatment. This is known as a gene-directed enzyme, pro-drug therapy.
They found that the mini circle DNA was 14 times more effective at delivery and even more successful at killing the cancerous tumour.
Interestingly, the plasmid delivery method didn't show any tumour cell killing, the Dr. said. Yet the mini circle DNA therapy killed more than half of the breast cancer cells in the mice.
According to the researcher, this new approach could effectively become a better cancer treatment option than chemotherapy down the road.
Conventional chemotherapy isn't able to differentiate between tumours and normal tissue, so it attacks it all, he said. This non-specificity can cause severe side effects and insufficient drug concentration in tumours.
With EVs, treatment can be targeted and because of their compatibility with the human body, this type of delivery could minimise the risk of unwanted immune responses that can come with other gene therapies.
If EVs prove to be effective in humans, it would be an ideal platform for gene delivery and it could be used in humans sooner than we expect, the researcher said.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
https://gscrochetdesigns.blogspot.com. one can see my crochet creations
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
Labels: combo therapy, extracellular vesicles (EVs), genetic material, kill cancer cells, mini treatment, nano-size cells, prodrug, therapeutic approach, toxic agents, transfers
posted by G S Iyer at 5:10 AM
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