Seizures may be predicted in people with epilepsy
Scientists have discovered a pattern of molecules
that appear in the blood before seizures, which may lead to the
development of an early warning system for epilepsy patients.
Researchers have discovered molecules in the blood that
are higher in people with epilepsy before a seizure happens.
These molecules are fragments of transfer RNAs (tRNAs), a chemical
closely related to DNA that performs an important role in building
proteins within the cell.
As per researchers involved in this study,
tRNAs are cut into fragments when cells are stressed. Higher levels of
the fragments in the blood could reflect that brain cells are under
stress in the build-up to a seizure event.
Using blood samples from people with epilepsy,
the researchers found that fragment levels of three tRNAs “spike” in the
blood many hours before a seizure.
“People with epilepsy often report that one of
the most difficult aspects of living with the disease is never knowing
when a seizure will occur,” said an
investigator, and the study’s lead author.
“The results of this study are very promising. We
hope that our tRNA research will be a key first step toward developing
an early warning system.”
The World Health Organisation estimates that more than 50 million people worldwide have epilepsy.
“New technologies to remove the unpredictability of uncontrolled seizures for people
with epilepsy are a very real possibility,” said a co-author on the paper.
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Labels: blood, cells are stressed, early warning, fragments, molecules, pattern, predict, RNAs, seizures, spike, tRNAs
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