New drug increases survival in young women with advanced breast cancer

New drug shows increased survival rate in young women with breast cancer. The drug works by inhibiting the activity of cancer-cell promoting enzymes.

The treatment is less toxic than traditional chemotherapy because it more selectively targets cancerous cells, blocking their ability to multiply.

The study, touted as one of the greatest advances in the filed of breast cancer treatment in recent decades, showed that the addition of cell-cycle inhibitor ribociclib increased survival rates to 70 % after 3 1/2 years. The mortality rate was 29 % less when patients, all under 59 and pre-menopausal, were randomly assigned a placebo.

The study focused on a form of breast cancer which is fueled by the hormone estrogen and which accounts for 2/3rds of all cases among younger women. It is generally treated by the therapies that block the hormone's production.

You actually can ger synergy or better response, better cancer kill, by adding one of these cell-cycle inhibitors on top of the hormone-blocking therapy, the Dr. said.

Breast cancer is the most common cancer among Indian women-approximately 25% of the female cancer cases in India are BC- with an age-adjusted rate of 25.8 cases per 100,00 women and a mortality rate of 12.7 per 100,000 women.

The new trial involved the analysis of 670 women with stage 4 advanced cancer for which they had not received prior hormone-blocking therapy. These are patients who tend to be diagnosed later, at a later stage in their disease, because we don't have great screening modalities for young women, he said.

In addition, patients who develop breast cancer early tend to have more complex cases.
That's what makes us so excited because it's a therapy that's affecting so many patients with advanced disease,  he added.

A pill is administered daily for 21 days followed by 7 days off to allow the body time to recover since 2/3rds of patients have a moderate to severe drop in white cell count.

A spokesperson who markets the drug under the brand name Kisqali and funded the research, said it cost 12,553$ for a 28 day dose. There is no cure for metastatic breast cancer and the majority of the women on the drug will require some form of therapy for the rest of their lives.

Moving forward, she said she was interested in investigating whether ribociclib could help nip cancer in the bud at an earlier stage.

We want to go and look at those women diagnosed with early-stage disease, small tumours, tumours that haven't gone to the lymph nodes or haven't gone to other parts of the body and see if we can stop it from returning later from metastasizing, she said.

The enrollment phase of a new global clinical trial is now underway.

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Read more at Speciality Medical Dialogues: New drug increases survival in young women with advanced breast cancer https://speciality.medicaldialogues.in/new-drug-increases-survival-in-young-women-with-advanced-breast-cancer/