Wednesday, March 06, 2019

IBD and gut inflammation

The term IBD mainly covers two conditions, Crohn's disease and ulcerative colitis, whose principal feature is long-term inflammation of the intestines. The protracted inflammation eventually damages the tissue of the gut.

The main difference between these conditions is that Crohn's disease can occur anywhere in the gut between the mouth and the anus, while ulcerative colitis affects the colon and rectum.

According to 2015 survey data in a study, about 3 million adults in the United States have reported ever having had a diagnosis of IBD.

This figure suggests that at least 1.3 percent of the U.S. adult population has IBD, which often occurs with other illnesses and results in poor quality of life and "complications requiring hospitalizations and surgical procedures."

The main symptoms of IBD are abdominal pain and diarrhea. People with ulcerative colitis can also experience bleeding through the anus.

The risk factors for IBD include "genetic predisposition and factors that alter gut microbiota, such as antibiotics," note the study authors.

For a while, experts thought that IBD was a " classic autoimmune" disease, wherein the immune system attacks the tissue of the gut as if it were a threat similar to that of disease-causing viruses and bacteria.

More recently, however, other explanations about the origins of IBD have emerged, and there is a growing view that Crohn's disease and ulcerative colitis are "complex barrier disorders."

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