Common heart drug may up sudden cardiac arrest risk

A  drug commonly used to treat high blood pressure and chest pain could be associated with an increased risk of sudden cardiac arrest, according to a study. 

Doctors examined over 60,000 people to determine whether nifedipine and amlodipine or dihydropyridines — widely used for high blood pressure and angina — were linked with out-of-hospital cardiac arrest.

The results, showed that high-dose (60 mg/day) nifedipine was significantly associated with an increased risk of out-of-hospital cardiac arrest with any dose of amlodipine.

There was no risk associated with amlodipine.

“Nifedipine and amlodipine are often used by many cardiologists and other physicians, and the choice often depends on the prescriber’s preference and personal experience,” said a cardiologist.

The findings are surprising given that both the drugs have been in use for many years.

However, the researchers urged caution when interpreting the results.

“The findings need to be replicated in other studies before action could be taken by doctors or patients,” the Dr. said.

In sudden cardiac arrest, the heart stops pumping after a cardiac arrhythmia (ventricular fibrillation/tachycardia). This can be lethal if untreated. 

 

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