Genetic test could help fight secondary breast cancer
Thousands of breast cancer patients at risk of developing aggressive
secondary tumours could benefit from a potential new genetic test.
A study led by researchers has shown women with breast cancer who lack a key genetic marker are more likely to respond to a treatment that can prevent the disease spreading to their bones.
Secondary cancer, known as metastasis, is the most common cause of death in breast cancer patients as there are few effective treatments once it has taken root.
It occurs when cancer cells spread to another site in the body. Around 70 per cent of secondary breast cancer patients have tumours in the bone.
Large scale clinical trials indicate a group of bone strengthening drugs known as bisphosphonates can help prevent the disease from spreading to bone in breast cancer patients if given early enough.
"The difficulty is identifying which patients will benefit from these drugs," said a professor of medical oncology who led the new study.
"It only seems to be effective in some patients, particularly older women, while others show no response and in some younger women it may even be harmful," Prof. said.
The new study has shown it may be possible to identify women who will benefit from bisphosphonates by using a test that looks for a gene known as MAF.
Women who do not carry the gene -- approximately 80 per cent of women with breast cancer -- were found to benefit from the bone strengthening treatment.
"If the test is negative for this gene, then they can be offered this bone strengthening treatment, which can give them a better chance of surviving their cancer," Coleman said.
"The discovery made and tested in the current study could be of great use to clinicians and would avoid unnecessary treatment of patients who would not benefit or could be harmed by the treatment," said Professor.
A test for the gene, known as MAFTest, has been developed by a medical company called Inbiomotion.
The study was part of an international phase 3 clinical trial involving 3,360 women with stage II or III breast cancer.
The results need to be confirmed in a second trial, currently underway, before the test is likely to receive approval for wider use in patients.
If successful, it could be incorporated into the routine testing of breast cancer patients to see if they could benefit from bisphosphonate treatments such as zoledronic acid.
Those found not to carry the gene could be given the drug after having surgery and radiotherapy for their primary tumour in an effort to prevent the cancer from spreading.
Around more than 50,000 women are diagnosed with breast cancer each year and the disease claims the lives of at least 11,500 annually.
A study led by researchers has shown women with breast cancer who lack a key genetic marker are more likely to respond to a treatment that can prevent the disease spreading to their bones.
Secondary cancer, known as metastasis, is the most common cause of death in breast cancer patients as there are few effective treatments once it has taken root.
It occurs when cancer cells spread to another site in the body. Around 70 per cent of secondary breast cancer patients have tumours in the bone.
Large scale clinical trials indicate a group of bone strengthening drugs known as bisphosphonates can help prevent the disease from spreading to bone in breast cancer patients if given early enough.
"The difficulty is identifying which patients will benefit from these drugs," said a professor of medical oncology who led the new study.
"It only seems to be effective in some patients, particularly older women, while others show no response and in some younger women it may even be harmful," Prof. said.
The new study has shown it may be possible to identify women who will benefit from bisphosphonates by using a test that looks for a gene known as MAF.
Women who do not carry the gene -- approximately 80 per cent of women with breast cancer -- were found to benefit from the bone strengthening treatment.
"If the test is negative for this gene, then they can be offered this bone strengthening treatment, which can give them a better chance of surviving their cancer," Coleman said.
"The discovery made and tested in the current study could be of great use to clinicians and would avoid unnecessary treatment of patients who would not benefit or could be harmed by the treatment," said Professor.
A test for the gene, known as MAFTest, has been developed by a medical company called Inbiomotion.
The study was part of an international phase 3 clinical trial involving 3,360 women with stage II or III breast cancer.
The results need to be confirmed in a second trial, currently underway, before the test is likely to receive approval for wider use in patients.
If successful, it could be incorporated into the routine testing of breast cancer patients to see if they could benefit from bisphosphonate treatments such as zoledronic acid.
Those found not to carry the gene could be given the drug after having surgery and radiotherapy for their primary tumour in an effort to prevent the cancer from spreading.
Around more than 50,000 women are diagnosed with breast cancer each year and the disease claims the lives of at least 11,500 annually.
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE
HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.
PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-
HTTP:GSEASYRECIPES.BLOGSPOT.COM/
FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-
FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-
HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/
FOR CROCHET DESIGNS
HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM
FOR CROCHET DESIGNS
HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM
Labels: aggressive tumours, bone strengthening drug, Fight, genetic test, genetic markers, secondary breast cancer
posted by G S Iyer at 10:05 PM
0 Comments:
Post a Comment
<< Home