Faulty immune system causes depression

Depression is a physical illness caused by a faulty immune system that may be treated using anti-inflammatory drugs, scientists say. Current treatments for depression focus on restoring serotonin and other mood-boosting chemicals in the brain.

However, researchers  have found that an overactive immune system triggers inflammation throughout the entire body, sparking feelings of hopelessness, unhappiness and fatigue. It may be a symptom of the immune system failing to switch off after a trauma or illness, and is a similar to the low mood people often experienced when they are fighting a virus, like flu.

Recent studies and clinical trials have shown that treating inflammation seems to alleviate depression,researchers said. “It is pretty clear that inflammation can cause depression,” said  a Professor.  “In relation to mood, beyond reasonable doubt, there is a very robust association between inflammation and depressive symptoms,” he said.

Scientists are hoping to begin trials next year to test whether anti-inflammatory drugs could switch off depression. The immune system triggers an inflammatory response when it feels it is under threat, sparking wide-ranging changes in the body such as increasing red blood cells, in anticipation that it may need to heal a wound soon. Scientists believe that associated depression may have brought an evolutionary benefit to our ancestors. If an ill or wounded tribal member became depressed and withdrawn it would prevent a disease being passed on.

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