World’s first birth from frozen ovary
In a medical breakthrough, a 28-year-old woman has become the first
person in the world to give birth to a healthy baby using ovarian tissue
that was removed and frozen in her childhood.
Previous successful transplants resulting in pregnancies have used
frozen ovary tissue removed from adult women, but this is the first time
ovarian tissue was taken from a girl when she was just 13 years and
11-months old.
It was not known whether tissue taken from girls before puberty could develop to produce mature eggs.
The breakthrough, described in the journal Human Reproduction, gives
hope to thousands of young cancer victims that face treatments such as
chemotherapy which can damage the ovaries, leaving them infertile.
The patient, who was born in the Republic of Congo but moved to Belgium
aged 11, had received a transplant of her brother’s bone marrow to treat
her sickle-cell anaemia.
The procedure required chemotherapy to disable the immune system and prevent rejection of the bone marrow, The Times reported.
Doctors removed her right ovary just before she turned 14 and froze
tissue fragments. Puberty and breast development had begun but she had
not started her periods.
The treatment left her with no functioning ovary and when she was 15
doctors began hormone replacement therapy (HRT) to induce menstruation.
Ten years later, she decided to start a family and doctors, led by
Isabelle Demeestere, a gynaecologist and research associate at Erasme
Hospital, Universite Libre de Bruxelles, stopped the HRT and grafted
four fragments of the frozen ovarian tissue on to the remaining left
ovary and other fragments in the surrounding area.
The transplanted tissue started to respond to her hormones and grew
follicles containing maturing eggs. Her periods began five months later.
After two years, she became pregnant naturally with her partner and delivered a healthy boy in November last year.
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Labels: birth, chemotherapy, frozen ovary, infertility, tissues
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