Major hurdle to diabetes transplants removed
Researchers have identified a way to make insulin-producing human cells multiply in the
laboratory, potentially removing a significant obstacle to transplanting the cells as a
treatment for patients with type diabetes.
Efforts to make this treatment possible have been limited by a dearth of insulin-producing
beta cells that can be removed from donors after death, and by the stubborn refusal of
human beta cells to proliferate in the laboratory after harvesting.
The new technique uses a cell conditioning solution originally developed to trigger
reproduction of cells from the lining of the intestine.
"Until now, there didn't seem to be a way to reliably make the limited supply of human beta
cells proliferate in the laboratory and remain functional. We have not only found a technique
to make the cells willing to multiply, we've done it in a way that preserves their ability to
make insulin," said a professor of pathology and immunology.
Lead author reported on his work with beta cells and was approached by an associate
professor of pathology and immunology, who studies autoimmune problems in the gut.
He had developed a medium that causes cells from the intestine's lining to proliferate in test
tubes.
The ability to produce large quantities of human beta cells in the laboratory gives the
researchers hope that they could one day be transplanted into patients with type 1 diabetes.
If the new availability of laboratory-grown beta cells makes it possible to treat patients with
transplants from one donor instead of multiple donors, he noted, that might reduce the risk
of immune system rejection of the transplants.
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Labels: beta cells, human, immune system, insulin, intestines, rejection, transplants, Type 1 diabetes
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