High BP drug could treat skin cancer
Researchers have discovered by accident cancer-fighting properties in a drug typically used to treat high blood pressure.
The drug carvedilol can protect against the sun-induced cell damage that leads to skin cancer, the findings showed.
“What began as an experimental error led to a very interesting scientific discovery,” said co-leader of the research team Ying Huang from Western University of Health Sciences College of Pharmacy, California, US.
“Our research could lead to the development of a class of new cancer-preventive agents,” Huang said.
The findings are scheduled to be presented at the American Society for Pharmacology and Experimental Therapeutics annual meeting during the Experimental Biology 2017 meeting being held from April 22-26 in Chicago.
Carvedilol’s cancer-fighting properties were discovered when a former graduate student in Huang’s lab was studying whether carvedilol and similar beta blockers might increase cancer risk.
The student inadvertently tested carvedilol’s ant-icancer effect rather than its ability to promote cancer, finding that carvedilol surprisingly showed some protective effects against skin cancer.
The
researchers then conducted experiments with cell cultures and mice to
see if carvedilol could prevent skin cancer caused by ultraviolet-B
(UVB), the portion of sunlight that tends to damage the skin’s top
epidermal layers and plays a key role in skin cancer development.
The researchers found that carvedilol exhibited a protective effect in cultured mouse skin cells exposed to UVB and in hairless mice given the drug after UVB exposure.
The experiments showed that carvedilol acted by protecting cells against the cancer-causing DNA damage and cell death produced by UVB.
Hairless mice exposed to UVB and given carvedilol showed decreases in both the severity and number of tumours that developed compared to those not given carvedilol.
The mouse studies also showed that carvedilol delayed skin tumour formation more than sunscreen.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
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The drug carvedilol can protect against the sun-induced cell damage that leads to skin cancer, the findings showed.
“What began as an experimental error led to a very interesting scientific discovery,” said co-leader of the research team Ying Huang from Western University of Health Sciences College of Pharmacy, California, US.
“Our research could lead to the development of a class of new cancer-preventive agents,” Huang said.
The findings are scheduled to be presented at the American Society for Pharmacology and Experimental Therapeutics annual meeting during the Experimental Biology 2017 meeting being held from April 22-26 in Chicago.
Carvedilol’s cancer-fighting properties were discovered when a former graduate student in Huang’s lab was studying whether carvedilol and similar beta blockers might increase cancer risk.
The student inadvertently tested carvedilol’s ant-icancer effect rather than its ability to promote cancer, finding that carvedilol surprisingly showed some protective effects against skin cancer.
The researchers found that carvedilol exhibited a protective effect in cultured mouse skin cells exposed to UVB and in hairless mice given the drug after UVB exposure.
The experiments showed that carvedilol acted by protecting cells against the cancer-causing DNA damage and cell death produced by UVB.
Hairless mice exposed to UVB and given carvedilol showed decreases in both the severity and number of tumours that developed compared to those not given carvedilol.
The mouse studies also showed that carvedilol delayed skin tumour formation more than sunscreen.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
https://gscrochetdesigns.blogspot.com. one can see my crochet creations
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
Labels: drug-carvedilol, High BP, protects against, Skin cancer, sun-induced cell
posted by G S Iyer at 1:56 AM
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