Malaria drug may help in cancer fight
Clinical tests will prove if we can show the same results in cancer patients," said the lead author.
An off-patent malaria drug could help to destroy cancer cells by making them more susceptible to radiotherapy, according to early work that has prompted British scientists to start a clinical trial.
Researchers reported on Monday that atovaquone boosted oxygen levels in tumour cells in mice, making radiotherapy more effective against a range of cancer types, including lung, bowel, brain and head and neck cancer.
Cancer cells with low oxygen levels are more difficult to treat with radiotherapy and are more likely to spread to other parts of the body. "We have now started a clinical trial ...to see if we can show the same results in cancer patients," said lead researcher Gillies McKenna of the Cancer Research UK Radiation Research Centre in Oxford.
"We hope that this existing low-cost drug will mean that resistant tumours can be re-sensitised to radiotherapy. And we're using a drug that we already know is safe." His team's findings were published in the journal Nature Communications. The idea of repurposing existing drugs to fight cancer is gaining traction as scientists realise that older medicines can sometimes complement other therapies.
The fact that such drugs are already off patent means they are cheap, but the lack of patent protection is also a potential problem because drug companies investing in late-stage research have less certainty of a commercial payback.
Atovaquone is used to both treat and prevent malaria. It is usually prescribed to travellers as Malarone, a combination of atovaquone and proguanil developed by GlaxoSmithKline.
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An off-patent malaria drug could help to destroy cancer cells by making them more susceptible to radiotherapy, according to early work that has prompted British scientists to start a clinical trial.
Researchers reported on Monday that atovaquone boosted oxygen levels in tumour cells in mice, making radiotherapy more effective against a range of cancer types, including lung, bowel, brain and head and neck cancer.
Cancer cells with low oxygen levels are more difficult to treat with radiotherapy and are more likely to spread to other parts of the body. "We have now started a clinical trial ...to see if we can show the same results in cancer patients," said lead researcher Gillies McKenna of the Cancer Research UK Radiation Research Centre in Oxford.
"We hope that this existing low-cost drug will mean that resistant tumours can be re-sensitised to radiotherapy. And we're using a drug that we already know is safe." His team's findings were published in the journal Nature Communications. The idea of repurposing existing drugs to fight cancer is gaining traction as scientists realise that older medicines can sometimes complement other therapies.
The fact that such drugs are already off patent means they are cheap, but the lack of patent protection is also a potential problem because drug companies investing in late-stage research have less certainty of a commercial payback.
Atovaquone is used to both treat and prevent malaria. It is usually prescribed to travellers as Malarone, a combination of atovaquone and proguanil developed by GlaxoSmithKline.
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
https://gscrochetdesigns.
https://gseasyrecipes.
https://kneereplacement-
Labels: atovaquone, boosted oxygen levels, bowel cancer, brain cancer, effective, fight cancer, head and neck cancer, lung cancer, malaria drug, radiotherapy
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