Nisin: A natural food preservative that can kill cancer cells

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Nisin, a naturally occurring food preservative that grows on dairy products, delivers a one-two punch to two of medicine’s most lethal maladies: cancer and deadly, antibiotic-resistant bacteria.
Researchers focused on the cancer-killing properties of nisin, a colorless, tasteless powder widely used as a food preservative.
“The application of nisin has advanced beyond its role as a food biopreservative,” said researcher Yvonne Kapila, professor at University of Michigan School of Dentistry in the US.

“Current findings and other published data support nisin’s potential use to treat antibiotic resistant infections, periodontal disease and cancer,” Kapila noted.

The researchers found that feeding rats a “nisin milkshake” killed 70-80 percent of head and neck tumour cells after nine weeks and extended survival.

The mice were given a highly purified nisin dosage of 800 mg/kg. Nisin is typically added to food at the rate of .25 to 37.5 mg/kg. Many foods contain nisin, but nowhere near the 800 mg/kg needed to kill cancer cells.

Several products available to consumers also contain nisin - creams and pharmaceuticals to fight infection and mastitis, and a sanitiser in lactating cows.
 
Nisin also fights deadly bacteria such as antibiotic-resistant MRSA (methicillin-resistant Staphylococcus aureus). 

“To date, nobody had found bacteria from humans or living animals that is resistant to nisin,” Kapila said.

While promising, the results are small and in mice only, so it is too early to say if nisin will act the same way in humans, Kapila said.
The findings will appear in a forthcoming issue of the Journal of Antimicrobial Chemotherapy.