Why diabetic women are likelier to develop kidney failure than men?

A new study has linked a genetic variant on chromosome 2 with kidney failure in diabetic women but not in men.

A researcher had designed a study to detect genetic variants that might predispose diabetic women to kidney failure and identified a genetic variant on chromosome 2 that was linked with kidney failure in women with type 1 diabetes but not in men.

Diabetic women with the risk variant had a nearly twofold increased risk of developing kidney failure compared with diabetic women who did not have the risk variant.

The genetic variant is located close to a gene for a factor that interacts with the estrogen receptor and also helps regulate kidney function. It will be interesting to see if this factor plays a role in the gender-specific protection against kidney failure seen in this study.

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