Second person to be HIV-free spells hope for the global Aids fight
For the second time in history, a person carrying the Human Immunodeficiency Virus (HIV) has been cured. Almost
12 years after the first person became HIV-free, doctors have managed
to replicate that success, something medical professionals all over the
world tried long and hard to do. An article details how the second patient is in “long-term remission”, similar to the first one.
How does this ‘cure’ work?
The researchers prefer publicly calling the treatment a “long-term
remission” because the idea of this being a fool-proof cure for HIV is
inaccurate. It is difficult to officially designate a treatment as a “cure” if there are only two known instances of it, they add. Nonetheless, both treatments have a commonality: bone-marrow
transplants. The transplants initially intended to treat cancer in the
two patients. A California resident,
initially known only as the “Berlin patient”, became the first to be
HIV-free. He had two stem cell transplants that cleared his body of HIV, according to reports. It is reported that both patients’ immune systems were first “wiped out” via
chemotherapy and then replaced with stem cell transplants and
non-malignant donor cells. The bone marrow transplants infused their body with much-needed immunity, which then resisted the spread of HIV. Such
a transplant is not a realistic mass technique yet because it is very
risky, has serious complications, and is difficult to replicate. The report says that despite efforts to duplicate Brown’s treatment, patients
tested positive around nine months after they stopped taking anti-HIV
drugs. However, the second person, who prefers to remain
anonymous and is being called the “London patient”, has been off
anti-HIV drugs for over 16 months now and has tested negative for the
virus.
Hope for future treatments?
Currently, doctors prescribe
anti-HIV drugs, such as non-nucleoside reverse transcriptase inhibitors
or entry inhibitors, that not only prevent HIV cells from duplication
but also prevent them from entering white blood cells. However, Brown’s doctor said, “By repeating the procedure in another patient, there is more evidence that the ‘Berlin patient’ is not an exception.” The London patient’s treatment was also much less harsh than Brown’s, giving medical professionals and patients renewed hope. The London patient told the reporters, “I feel a sense of responsibility to help doctors understand how it happened so they can develop the science.”
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